Methods of monitoring the modulation of the kinase activity of fibroblast growth factor receptor and uses of said methods

摘要

The disclosure relates to use of inorganic phosphorus (P) or the product of phosphorus and total calcium (P x tCa) as a biomarker for monitoring the inhibition of kinase activity of fibroblast growth factor receptor (FGFR) and for determining therapeutic efficacy and/or one or more secondary effects of FGFR inhibitor, wherein the secondary effect is ectopic mineralization, and wherein the FGFR inhibitor is selected from compound A (3-(2,6-Dichloro-3,5-dimethoxy-phenyl)-1-{6-[ 4-(4-ethyl-piperazin-1-yl)-phenylamino]-pyrimidin-4-25 yl}-1-methyl urea), TKI258, or a pharmaceutically acceptable salt thereof.