| 摘要 |
<p>Disclosed is a mutein of human tear lipocalin having binding affinity to IL-4 receptor alpha, characterised in at least one substitution at a position corresponding to the amino acid position of mature human tear lipocalin selected from the group consisting of: Pro, Leu, Asn,Tyr, Lys or Glu at position 26; Lys at position 32; Trp, Asn, Val, His or Arg at position 34;Leu, Ala, His, Lys or Met at position 56; Leu at position 58; or Lys, Ser, Gln or Pro at position 63, wherein the mutain has a stronger binding affinity than S191.5-B24.</p> |
