| 摘要 |
Disclosed is a mouse model of Thrombotic Thrombocytopenic Purpura (TTP) comprising a transgenic mouse, wherein the transgenic mouse expresses recombinant human von Willebrand factor (rVWF) from a transgene comprising a polynucleotide encoding rVWF, wherein the rVWF composition forms high molecular weight multimers, and wherein the expression results in a symptom of TTP selected from the group consisting of: reduced platelet levels, anemia, histopathological effects, increased blood creatinine kinase levels, increased lactate dehydrogenase levels, and increased microthrombi., Also disclosed is a method of inducing symptoms of Thrombotic Thrombocytopenic Purpura (TTP) in a mouse, said method comprising the step of administering to the mouse a composition comprising recombinant human von Willebrand factor (rVWF) in an amount effective to result in a symptom of TTP, wherein the rVWF composition forms high molecular weight multimers, and wherein the symptom of TTP in the mouse is selected from the group consisting of: reduced platelet levels, anemia, histopathological effects, increased blood creatinine kinase levels, increased lactate dehydrogenase levels, and increased microthrombi. |
