发明名称 |
GASTRO-RETENTIVE SUSTAINED-RELEASE ORAL DOSAGE FORM OF A BILE ACID SEQUESTRANT |
摘要 |
Disclosed herein are novel compositions and methods for controlling the release of bile acid sequestrant to the stomach in order to treat or prevent upper GI tract disorders or disorders of the throat. The methods generally include administering to a patient in need thereof a therapeutically effective amount of a pharmaceutical composition comprising at least one bile acid sequestrant dispersed in a polymeric matrix. The bile acid sequestrant composition may be administered alone or in combination with at least one proton pump inhibitor, and optionally one or more agents chosen from antacids, histamine H2-receptor antagonists, γ-aminobutyric acid-&bgr; (GABA-B) agonists, prodrugs of GABA-B agonists, acid pump antagonists, protease inhibitors and GC-C agonists. |
申请公布号 |
WO2014113377(A1) |
申请公布日期 |
2014.07.24 |
申请号 |
WO2014US11450 |
申请日期 |
2014.01.14 |
申请人 |
IRONWOOD PHARMACEUTICALS, INC.;SETHURAMAN, VASU;HEDDEN, DAVID BRUCE;LESKOW, KRISTEN MARIE |
发明人 |
SETHURAMAN, VASU;HEDDEN, DAVID BRUCE;LESKOW, KRISTEN MARIE |
分类号 |
A61K9/00;A61K9/28;A61K31/785 |
主分类号 |
A61K9/00 |
代理机构 |
|
代理人 |
|
主权项 |
|
地址 |
|