发明名称 OPTIMIZED ANTIBODIES THAT TARGET HM1.24
摘要 The present disclosure describes antibodies that target HM1.24. In various aspects, the antibodies have specific CDR, variable, or full length sequences, have modifications with the parent antibody, or include at least one modification relative to a parent antibody that alters affinity to an FcγR or alters effector function as compared to the parent antibody. Nucleic acids encoding the antibodies and methods of using the antibodies are also disclosed.
申请公布号 US2014205605(A1) 申请公布日期 2014.07.24
申请号 US201313794676 申请日期 2013.03.11
申请人 XENCOR, INC. 发明人 Bernett Matthew J.;Desjarlais John R.;Karki Sher Bahadur;Lazar Gregory Alan;Muchhal Umesh S.;Nguyen Duc-Hanh Thi;Richards John O.
分类号 C07K16/28;A61K39/395;A61K31/573;A61K31/69;A61K31/454 主分类号 C07K16/28
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