DUAL ACTION INHIBITORS AGAINST HISTONE DEACETYLASES AND 3-HYDROXY-3-METHYLGLUTARYL COENZYME A REDUCTASE

摘要

Disclosed herein are novel compounds of formula (I), and uses thereof. The compounds of Formula (I) are inhibitors of histone deacetylases (HDACs) and 3-hydroxy-3-methylglutaryl coenzyme A (HMG-CoA) reductase (HMGR). Also provided are methods of using the compounds of Formula (I) for inhibiting the activity of HDACs and HMGR, treating diseases associated with HDACs or HMGR (e.g., cancer, hypercholesterolemia, an acute or chronic inflammatory disease, autoimmune disease, allergic disease, pathogen infection, neurodegenerative disease, or a disease associated with oxidative stress,;

主权项

1. A compound of formula (I), or its pharmaceutically acceptable salt, solvate, derivative or prodrug, wherein: x is an integral from 1 to 3; L1 is ethylene; L2 is independently carbon or oxygen; or L1 and L2 together are deleted; L3 is 4-phenyl-1,2,3-triazolyl, provided that L2 is carbon, and x is 1; or L1 and L2 together are deleted; L4 is null or C1-9 alkylene, provided that L1 is ethylene, L2 is oxygen, when L4 is null; R1 is H, aralkyl or alkylsilyl; and R2 is H or alkyl.