| 发明名称 |
Stromal Derived Factor Inhibition And CXCR4 Blockade |
| 摘要 |
The invention relates to inhibition of SDF-1α expression in subacromial bursa cells by CXCR-4 inhibitors. Bursal cell migration in response to SDF-α stimulation is also decreased in the presence of CXCR4 inhibitors. Accordingly, provided are methods for treating or ameliorating a musculoskeletal disorder. |
| 申请公布号 |
US2014206629(A1) |
申请公布日期 |
2014.07.24 |
| 申请号 |
US201213985415 |
申请日期 |
2012.02.17 |
| 申请人 |
Blaine Theodore A. |
发明人 |
Blaine Theodore A. |
| 分类号 |
C07D295/135;C07C211/27;A61K38/10;C07C237/30;C07D233/88;C07C257/18;C07D233/64 |
主分类号 |
C07D295/135 |
| 代理机构 |
|
代理人 |
|
| 主权项 |
1. A method for treating or ameliorating a musculoskeletal disorder in a subject in need thereof, comprising administering to said subject a compound that inhibits or reduces binding or expression of Stromal Cell-Derived Factor-1α (SDF-1α) and CXCR4, thereby treating or ameliorating said musculoskeletal disorders. |
| 地址 |
Old Greenwich CT US |
