发明名称 |
Opioid Prodrugs with Heterocyclic Linkers |
摘要 |
The embodiments provide prodrug compounds of Formulae I-XV. The present disclosure also provides compositions, and their methods of use, where the compositions comprise a prodrug compound of Formulae I-XV that provides controlled release of an opioid. Such compositions can optionally provide a trypsin inhibitor that interacts with the enzyme that mediates the controlled release of an opioid from the prodrug so as to attenuate enzymatic cleavage of the prodrug. |
申请公布号 |
US2014206597(A1) |
申请公布日期 |
2014.07.24 |
申请号 |
US201414166719 |
申请日期 |
2014.01.28 |
申请人 |
Signature Therapeutics, Inc. |
发明人 |
Jenkins Thomas E.;Husfeld Craig O. |
分类号 |
A61K47/48;A61K31/485 |
主分类号 |
A61K47/48 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
Palo Alto CA US |