METHODS FOR INDUCING SYSTEMIC IMMUNE RESPONSES TO CANCER

摘要

Pharmaceutical compositions comprising molecules produced by antigen-stimulated peripheral blood mononuclear cells (PBMCs) that induce systemic immune responses to cancers are encompassed herein, as are methods for making and administering such molecules and pharmaceutical compositions comprising same. Also encompassed herein are mixtures of molecules produced by antigen-stimulated PBMCs and compositions thereof for use in treating cancer. Methods for stimulating a systemic immune response in a subject afflicted with a cancer are also envisioned, whereby molecules produced by antigen-stimulated PBMCs or supernatants comprising same are administered to the subject, wherein the molecules stimulate an immune response to the cancer in the subject.

主权项

1. A method for inducing a systemic immune response to a metastatic cancer in a subject, the method comprising administering supernatants from activated peripheral blood mononuclear cells (PBMCs) to the subject, wherein the supernatants are administered intratumorally and repeatedly.