发明名称 |
AMPHIPHILIC CATIONIC POLYMERS FOR THE DELIVERY OF THERAPEUTIC AGENTS |
摘要 |
Amphiphilic cationic polymers comprising a biocompatible amphiphile linked to an organic cation are provided. The polymers complex with therapeutic agents and facilitate delivery of such therapeutic agents, particularly therapeutic nucleic acids, both in vitro and in vivo. Accordingly, the invention further provides methods of facilitating delivery of therapeutic and/or diagnostic agents to a cell and methods of treating a condition, such as a disease or infection, in an organism using the amphiphilic cationic polymers of the invention. |
申请公布号 |
EP2755636(A1) |
申请公布日期 |
2014.07.23 |
申请号 |
EP20120766800 |
申请日期 |
2012.09.14 |
申请人 |
THE CHARLOTTE-MECKLENBURG HOSPITAL AUTHORITY D/B/A CAROLINAS HEALTHCARE SYSTEM |
发明人 |
WANG, MINGXING;LU, QILONG;WU, BO;LU, PEIJUAN |
分类号 |
A61K9/107;A61K9/00;A61K47/34;A61K48/00;A61P21/00 |
主分类号 |
A61K9/107 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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