COMPOSITIONS COMPRISING ALTERNATING 2'-MODIFIED NUCLEOSIDES FOR USE IN GENE MODULATION
摘要
The present invention provides compositions comprising at least one oligomeric compound comprising an alternating motif and further include a region that is complementary to a nucleic acid target. The compositions are useful for targeting selected nucleic acid molecules and modulating the expression of one or more genes. In preferred embodiments the compositions of the present invention hybridize to a portion of a target RNA resulting in loss of normal function of the target RNA. The present invention also provides methods for modulating gene expression.
申请公布号
CA2504929(C)
申请公布日期
2014.07.22
申请号
CA20032504929
申请日期
2003.11.04
申请人
ISIS PHARMACEUTICALS, INC.
发明人
ALLERSON, CHARLES;BHAT, BALKRISHEN;ELDRUP, ANNE B.;MANOHARAN, MUTHIAH;GRIFFEY, RICHARD H.;BAKER, BRENDA F.;SWAYZE, ERIC E.