Compositions and methods of inducing endoplasmic reticulum stress response for the treatment of cell proliferative diseases

摘要

The present invention provides methods of inducing cell cycle arrest and/or cell growth inhibition, with the methods comprising administering to the cells an effective dose of the compounds of the present invention.

主权项

1. A method of causing an effect in a prostate cancer cell, wherein the effect is selected from the group consisting of inducing cell cycle arrest in a cell, inducing growth arrest in a cell and inducing apoptosis in a cell, the method comprising coadministering, sequentially or coextensively, to the prostate cancer cell of a patient in need thereof an effective dose of a combination of an amount of a compound of Formula II andand an amount of thapsigargin, wherein coadministration of the amount of the compound and the amount of thapsigargin to the cell causes said effect in the cell.