| 发明名称 | Solid forms of N-[2,4-bis(1,1-dimethylethyl)-5-hydroxyphenyl]-1,4-dihydro-4-oxoquinoline-3-carboxamide | ||
| 摘要 | The present invention relates to solid state forms of N-[2,4-bis(1,1-dimethylethyl)-5-hydroxyphenyl]-1,4-dihydro-4-oxoquinoline-3-carboxamide (Compound 1), pharmaceutical compositions thereof and methods therewith. | ||
| 申请公布号 | US8785476(B2) | 申请公布日期 | 2014.07.22 |
| 申请号 | US201213682075 | 申请日期 | 2012.11.20 |
| 申请人 | Vertex Pharmaceuticals Incorporated | 发明人 | Arekar Sneha G.;Johnston Steven C.;Krawiec Mariusz;Medek Ales;Mudunuri Praveen;Sullivan Mark Jeffrey |
| 分类号 | C07D215/56 | 主分类号 | C07D215/56 |
| 代理机构 | Honigman Miller Schwartz and Cohn LLP | 代理人 | Honigman Miller Schwartz and Cohn LLP ;Forbes Christopher C.;O'Brien Jonathan P. |
| 主权项 | 1. A method of treating or lessening the severity of a disease in a patient, wherein said disease is selected from cystic fibrosis, smoke induced COPD, pancreatitis, pancreatic insufficiency, hereditary emphysema, COPD, or dry-eye disease, said method comprising the step of administering to said patient an effective amount of crystalline N-[2,4-bis(1,1-dimethylethyl)-5-hydroxyphenyl]-1,4-dihydro-4-oxoquinoline-3-carboxamide characterized as Form C. | ||
| 地址 | Boston MA US | ||