Colloidal metal compositions and methods

摘要

The present invention comprises compositions and methods for delivery systems of agents, including therapeutic compounds, pharmaceutical agents, drugs, detection agents, nucleic acid sequences and biological factors. In general, these vector compositions comprise a colloidal metal, derivatized PEG (polyethylene glycol) and an agent. The invention also comprises methods and compositions for making such colloidal metal compositions and for treatment of cancer.

主权项

1. A method for detecting a solid tumor, comprising;
site-directed accumulation of a detection agent in a tumor achieved by administering to an organism having a solid tumor, a vector composition consisting of a pegylated colloidal gold metal particle, and at least one detection agent, wherein a polyethylene glycol (PEG) thiol derivative is covalently bound to the colloidal gold metal, wherein the detection agent is a radioactive detection agent, a fluoresescent detection agent, a chemiluminescent detection agent, or a magnetic detection agent, and detecting the composition, wherein detection of the composition indicates the presence of a solid tumor.