METHOD OF OBTAINING 2-AMINO-2-CYANOADAMANTANE DERIVATIVES

摘要

FIELD: chemistry.SUBSTANCE: invention relates to a novel method of obtaining 2-amino-2-cyanoadamantane derivatives of the given general formula, which can be applied as semi-products in a synthesis of biologically active amino acids, diamines and heterocyclic compounds. The method consists in a reaction of adamantanone-2 with derivatives of amines in the presence of potassium carbonate with heating. As amine derivatives used are aminonitriles from the group 2-N-cyclohexylamino-2-cyanopropane, 2-N-piperidino-2-cyanopropane, 2-N-benzylamino-2-cyanopropane with a molar ratio adamantanone-2:aminonitrile, equal to 1:1.2-1.5, and a temperature of 80-100°C. The process takes place in one stage for 60-70 min.EFFECT: method makes it possible to obtain derivatives of 2-amino-2-cyanoadamantane of the given general formula with the high output.3 ex