发明名称 |
PH-SENSITIVE HYALURONIC ACID DERIVATIVE AND USES THEREOF |
摘要 |
Disclosed is a pH-sensitive hyaluronic acid derivative, comprising at least one repeat unit as shown in the following formula (I), wherein HA represents a unit comprising N-acetyl-D-glucosamine and D-glucuronic acid, q represents an integer of 2 to 10,000; A represents a biocleavable linkage comprising at least one of hydrazone, acetal, ketal and imine; M represents at least one of a hydrophobic fragment, a hydrophilic fragment, and an amphiphilic fragment, and p represents the number of [A-M] directly grafted onto each HA unit, p represents an integer of 0 to 4, and the p of each HA unit is not 0 at the same time.; |
申请公布号 |
US2014199349(A1) |
申请公布日期 |
2014.07.17 |
申请号 |
US201114128376 |
申请日期 |
2011.12.29 |
申请人 |
Yang Jean-Dean;Chou Ayi-Man;Chen Jui-Hsiang;Liu Hsia-Wei;Wang Shian-Jy;Teng Tse-Min;Liang Hsiang-Fa;Wei Ming-Cheng;Lu Maggie J.M. |
发明人 |
Yang Jean-Dean;Chou Ayi-Man;Chen Jui-Hsiang;Liu Hsia-Wei;Wang Shian-Jy;Teng Tse-Min;Liang Hsiang-Fa;Wei Ming-Cheng;Lu Maggie J.M. |
分类号 |
A61K47/36;A61K9/107;A61K31/704 |
主分类号 |
A61K47/36 |
代理机构 |
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代理人 |
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主权项 |
1. A hyaluronic acid derivative, comprising a structure as shown in the following formula (I): In the formula, HA represents a unit comprising N-acetyl-D-glucosamine and D-glucuronic acid, q represents an integer of 2 to 10,000; A represents a biocleavable linkage comprising at least one of hydrazone, acetal, ketal and imine; M represents at least one of a hydrophobic fragment, a hydrophilic fragment, and an amphiphilic fragment, and p represents the number of [A-M] directly grafted onto each HA unit, p represents an integer of 0 to 4, and the p of each HA unit is not 0 at the same time; wherein the hyaluronic acid derivative is biodegradable and pH-sensitive, and linkages of the hyaluronic acid derivative are broken in acidic conditions. |
地址 |
Dayuan Township TW |