| 发明名称 |
ANTICANCER AGENT |
| 摘要 |
The invention relates to a method for preparing a bisphosphonate covalently bonded to a nanostructure. This invention also relates to a bisphosphonate having incorporated therein a radioisotope selected from 32p or 33P, preferably 33p, wherein the bisphosphonate is covalently bonded to a nanostructure directly or by way of a linker, and to the use thereof in a method of treating calcific tumours in a patient. |
| 申请公布号 |
US2014199240(A1) |
申请公布日期 |
2014.07.17 |
| 申请号 |
US201214130344 |
申请日期 |
2012.07.02 |
| 申请人 |
Zeevaart Jan Rijn;Mbianda Xavier Yangkou;Szucs Zoltan |
发明人 |
Zeevaart Jan Rijn;Mbianda Xavier Yangkou;Szucs Zoltan |
| 分类号 |
A61K51/04 |
主分类号 |
A61K51/04 |
| 代理机构 |
|
代理人 |
|
| 主权项 |
1. A method for producing a bisphosphonate, the method including the steps of:
providing a compound or nanostructure having carboxylic acid functional group/s; and reacting the compound or nanostructure with phosphoric acid and a chlorinating agent, in an organic solvent. |
| 地址 |
Brits District ZA |
