LIFTING GATE POLYDIMETHYLSILOXANE MICROVALVES AND PUMPS FOR MICROFLUIDIC CONTROL

摘要

The present disclosure relates to method, system for microfluidic control. One or more embodiments of the disclosure relate to pneumatically actuated “lifting gate” microvalves and pumps. In some embodiments, a microfluidic control module is provided, which comprises a plurality of pneumatic channels and a plurality of lifting gate valves configured to be detachably affixed to a substrate. The plurality of lifting gate valves are aligned with at least one fluidic channel on the substrate when affixed to the substrate. Each of the valves comprises: a pneumatic layer, a fluidic layer, and a pneumatic displacement chamber between the pneumatic layer and the fluidic layer. The fluidic layer has a first side facing the pneumatic layer and a second side facing away from the pneumatic layer, wherein the second side has a protruding gate configured to obstruct a flow of the fluidic channel when the fluidic layer is at a resting state.

主权项

1. A microfluidic control module comprising:
a plurality of pneumatic channels, each channel configured to deliver positive and/or negative pressure to a pneumatic displacement chamber; and a plurality of lifting gate valves configured to be detachably affixed to a substrate, the valves being aligned with at least one fluidic channel on the substrate when affixed to the substrate, wherein each of the valves comprises:
a pneumatic layer,a fluidic layer having a first side facing the pneumatic layer and a second side facing away from the pneumatic layer, wherein the second side has a protruding gate configured to obstruct a flow of the fluidic channel when the valves are attached to the substrate and the fluidic layer is at a resting state, anda pneumatic displacement chamber between the pneumatic layer and the fluidic layer, wherein the pneumatic displacement chamber is configured to use a negative opening pressure delivered by one of the pneumatic channels to actuate the fluidic layer, thereby lifting the protruding gate away from the substrate to allow the flow of the fluidic channel.