MULTIPLE GROWTH FACTOR COMPOSITIONS, METHODS OF FABRICATION, AND METHODS OF TREATMENT

摘要

Disclosed are compositions with sustained-release carriers associated with at least two different types of growth factors and methods of fabrication and treatments thereof. In some embodiments, simultaneous release of the growth factors may be preferred while in other embodiments, sequential release of the growth factors may be preferred. Application of at least two growth factors to an injury site, e.g., compromised cardiac tissue caused by, for example, myocardial infarction or ischemic heart failure, may better mimic and induce the complex growth factor signaling pathways necessary to improve cardiac function. When applied to a patient after a myocardial infarction or ischemic heart failure, multiple growth factors within a sustained-release carrier platform or platforms may cause a synergistic effect on injected cells intending to alleviate left ventricle remodeling. Methods of treatment include percutaneous, sub-xiphoid, and open chest methods using catheters and/or syringes.

主权项

1. A composition, comprising:
a first bioerodable carrier platform capable of sustained release of a first growth factor; at least one second different bioerodable carrier platform capable of sustained release of a second growth factor, wherein the second different bioerodable carrier platform comprises at least two precursors of a two-component hydrogel, wherein the at least two precursors are operable to have a first liquid state in which they are capable of separate delivery and a second semi-solid gel state which forms when the at least two precursors mix; and at least one cell type, wherein a rate of release of the first growth factor from the first bioerodable carrier platform is faster than a rate of release of the second growth factor from the second bioerodable carrier platform, and wherein the first growth factor and the second growth factor are different and each of the first growth factor and the second growth factor have a different function when delivered to the compromised cardiac tissue such that cell survival followed by cell homing is enhanced.