发明名称 |
METHOD FOR MANUFACTURING BLOCK COPOLYMER |
摘要 |
Providing a method for producing a compound represented by formula (1) from a compound represented by formula (2), by which the additive amount of an aryl (C1-C8) alkyl alcohol which may have a substituent and the amount of residual carboxyl groups of pAsp (polyaspartic acid) are controlled. A production method including obtaining a compound represented by formula (1) by allowing a compound represented by formula (2) to react with an aryl (C1-C8) alkyl alcohol which may have a substituent, and a carbodiimide-based compound in an amount of 2 (x+y) equivalents or more relative to the amount of carboxyl groups in formula (2) (sum of x and y), in a solvent at 15°C to 30°C for 2 hours to 48 hours, is used. |
申请公布号 |
EP2754682(A1) |
申请公布日期 |
2014.07.16 |
申请号 |
EP20120830758 |
申请日期 |
2012.08.31 |
申请人 |
NIPPON KAYAKU KABUSHIKI KAISHA |
发明人 |
YAMAMOTO KEIICHIROU;KITAGAWA MASAYUKI |
分类号 |
C08G73/10;A61K9/48;A61K47/34;A61P35/00;C08G65/333 |
主分类号 |
C08G73/10 |
代理机构 |
|
代理人 |
|
主权项 |
|
地址 |
|