发明名称 METHOD FOR MANUFACTURING BLOCK COPOLYMER
摘要 Providing a method for producing a compound represented by formula (1) from a compound represented by formula (2), by which the additive amount of an aryl (C1-C8) alkyl alcohol which may have a substituent and the amount of residual carboxyl groups of pAsp (polyaspartic acid) are controlled. A production method including obtaining a compound represented by formula (1) by allowing a compound represented by formula (2) to react with an aryl (C1-C8) alkyl alcohol which may have a substituent, and a carbodiimide-based compound in an amount of 2 (x+y) equivalents or more relative to the amount of carboxyl groups in formula (2) (sum of x and y), in a solvent at 15°C to 30°C for 2 hours to 48 hours, is used.
申请公布号 EP2754682(A1) 申请公布日期 2014.07.16
申请号 EP20120830758 申请日期 2012.08.31
申请人 NIPPON KAYAKU KABUSHIKI KAISHA 发明人 YAMAMOTO KEIICHIROU;KITAGAWA MASAYUKI
分类号 C08G73/10;A61K9/48;A61K47/34;A61P35/00;C08G65/333 主分类号 C08G73/10
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