PROCESS FOR THE SYNTHESIS OF TELAVANCIN, ITS PHARMACEUTICALLY ACCEPTABLE SALTS AS WELL AS AN N-PROTECTED IMINE-DERIVATIVE OF TELAVANCIN

摘要

The invention relates to a process for the preparation of telavancin, or a pharmaceutically acceptable salt thereof, wherein said process comprises an alkylation of vancomycin which provides N-protected-decylaminoethylvancomycin-imine, followed by an aminomethylation to obtain N-protected-telavancin-imine, which is then reduced and deprotected to provide telavancin, or a pharmaceutically acceptable salt thereof. Another embodiment refers to N-protected-telavancin-imine which is formed during the process of the invention.