Nanoparticle-stabilized capsule formulation for treatment of inflammation

摘要

A formulation for the delivery of an anti-inflammatory agent to a subject is described. In one particular application of the invention, the formulation comprises oil-based or aqueous droplets comprising indomethacin (1-(4-chlorobenzoyl)-5-methoxy-2-methyl-1-H-indole-3-acetic acid) or celecoxib (4-[5-(4-methylphenyl)-3-(trifluoromethyl) pyrazol-1-yl]benzenesulfonamide) stabilized by nanoparticles, particularly silica nanoparticles.

主权项

1. A nanoparticle-stabilised capsule formulation comprising
a discontinuous phase comprising droplets comprising:
an oil-based or lipidic medium carrier selected from the group consisting of:
triglyceride oils (medium or long-chained), soyabean oil, sunflower oil and almond oil,an anti-inflammatory agent selected from the group consisting of celecoxib and indomethacin, andan emulsifier selected from the group consisting of lecithin and oleylamine, wherein the anti-inflammatory agent is present in the discontinuous phase at a concentration in the range of 0.01 to 10 wt. %, wherein said droplets are stabilised with nanoparticles coated on the surface of the droplets, and wherein the nanoparticles are selected from the group consisting of silica nanoparticles, titania nanoparticles and latex nanoparticles.