| 发明名称 | Method of measuring the affinity of biomolecules | ||
| 摘要 | The invention provides a method of measuring the affinity of first and second biomolecules in which a first biomolecule is tethered by a first tether portion having a first tether portion length and a second biomolecule is tethered by a second tether portion having a second tether portion length, the method comprising determining binding of adjacent first and second biomolecules to each other, varying at least one of the first and second tether lengths and determining binding of the first and second biomolecules. The invention also provides apparatus suitable for use in the method of the invention. | ||
| 申请公布号 | US8778697(B2) | 申请公布日期 | 2014.07.15 |
| 申请号 | US200612094073 | 申请日期 | 2006.11.10 |
| 申请人 | Nanotether Discovery Science Limited | 发明人 | Dale Trevor Clive;Harwood Adrian John;Borri Paola |
| 分类号 | G01N33/53 | 主分类号 | G01N33/53 |
| 代理机构 | Hunton & Williams LLP | 代理人 | Hunton & Williams LLP |
| 主权项 | 1. A method of measuring the affinity of a first and a second biomolecule, wherein the first biomolecule is tethered by a first tether portion having a first tether portion length and a first tether persistence length and the second biomolecule is tethered by a second tether portion having a second tether portion length and a second tether persistence length, wherein the first and second biomolecules are tethered to a surface, such that swept volumes defined by the movement of each biomolecule overlap, so that the first and second biomolecules are able to bind to each other, said method comprising determining a proportion of the first and second biomolecules bound to each other. | ||
| 地址 | Cardiff GB | ||