Tamper resistant transdermal dosage form

摘要

The invention comprises a transdermal dosage form comprising an active agent component comprising an active agent and an adverse agent component comprising an adverse agent, wherein the active agent component defines at least one channel extending substantially there through.

主权项

1. A transdermal dosage form comprising:
an active agent component having a proximal, skin contacting surface and a distal surface and comprising an opioid agonist; an adverse agent component having a proximal surface and a distal surface and comprising an opioid antagonist; a backing; a barrier having a proximal surface and a distal surface that is interposed between the active agent component and the adverse agent component, wherein one or more channels extend completely from the proximal surface of the active agent component to the distal surface of the barrier and terminate prior to the proximal surface of the adverse agent component; wherein air is disposed in one or more channels; and wherein the barrier is permeable to a solvent selected from the group consisting of water, ethanol, ether, and mixtures thereof, and wherein the barrier is impermeable to diffusion of opioid agonist and opioid antagonist in the absence of said solvent.