Chemically defined vaccine stabiliser

摘要

The present invention relates to a stabilizer composition comprising an amino acid, and a sugar wherein all compounds are chemically defined; to a vaccine composition comprising such a stabilizer composition and a biological molecule and/or a micro-organism; to a method for preparing a pharmaceutical composition comprising admixing such a stabilizer composition with a biological molecule and/or a micro-organism; to the use of such a stabilizer composition, and of vaccines prepared therewith.

主权项

1. A vaccine stabiliser composition consisting of at least one amino acid, at least one sugar, at least one polyamine, and water, wherein all compounds in the composition are chemically defined by consisting of identical molecules, and wherein the polyamine is at least one polyamine selected from the group consisting of ethylene-diamine, cadaverine, putrescine, spermidine and spermine;
wherein the at least one sugar is selected from the group consisting of glucose, lactose, sucrose, maltose, trehalose, sorbitol, mannitol, and a combination thereof; and wherein the at least one amino acid is selected from the group consisting of glutamate, glycine, or a combination thereof.