| 发明名称 | Stable emulsion formulations | ||
| 摘要 | The present invention relates to injectable formulations of irritant agents, such as calcimimetics, that are pharmaceutically stable and demonstrate a reduced incidence of irritation, pain, phlebitis, precipitation and hemolysis upon injection. | ||
| 申请公布号 | US8779004(B2) | 申请公布日期 | 2014.07.15 |
| 申请号 | US200711738444 | 申请日期 | 2007.04.20 |
| 申请人 | Amgen, Inc. | 发明人 | Gore Anuradha;Navratil Anne;Neervannan Seshadri;Spancake Christopher W.;Zanon Roger |
| 分类号 | A01N33/02;A61K31/135;A61K31/7034;A61K31/428;A61K31/65;A61K31/43;A61K47/18;A61K31/423;A61K31/7048;A61K31/545;A61K9/00;A61K31/5513;A61K9/107 | 主分类号 | A01N33/02 |
| 代理机构 | Fitzpatrick, Cella, Harper & Scinto | 代理人 | Fitzpatrick, Cella, Harper & Scinto |
| 主权项 | 1. A pharmaceutical formulation comprising: an oil phase from 1 to 30% by weight containing cinacalcet freebase from 0.001 to 5% by weight; a phospholipid emulsifier from 0.1 to 5% by weight; and an aqueous phase containing a charge stabilizer, wherein the formulation is stable and has a protective effect against irritation caused by the cinacalcet freebase. | ||
| 地址 | Thousand Oaks CA US | ||