Process for production of purified chlorogenic acid-containing pharmaceutical preparation

摘要

Provided is a process for producing a purified chlorogenic acid-containing preparation, which is useful for the production of a chlorogenic acid-containing beverage with reduced developability of turbidity even in an acidic range.;The process for producing a purified chlorogenic acid-containing preparation according to the present invention includes a first step of dispersing or dissolving a chlorogenic acid-containing composition as a starting material in the presence of acid clay or activated clay in a mixed solvent of an organic solvent and water, a second step of removing a deposit from a dispersion or solution obtained by the first step, a third step of adjusting a concentration of chlorogenic acids and pH in a solution, which has been obtained by the second step, to from 1.5 to 10 mass % and from 2 to 4, respectively, and a fourth step of separating the deposit formed in a concentration-adjusted solution obtained by the third step.

主权项

1. A process for producing a purified chlorogenic acid-containing preparation, comprising:
dispersing or dissolving a chlorogenic acid-containing composition as a starting material in the presence of acid clay or activated clay in a mixed solvent of 10 to 95% of ethanol and water to form a dispersion or solution; removing a deposit from the dispersion or solution to obtain a first solution; concentrating the level of chlorogenic acids in the first solution and adjusting the pH of the first solution to a concentration of from 2.5 to 8 mass % and a pH of 2 to 3.5, respectively, to form a concentrated pH-adjusted solution; and separating a deposit from the concentrated pH-adjusted solution; and wherein said process further comprises (i) reducing the concentration of the ethanol in the first solution to 5 mass % or lower; and/or (ii) reducing the concentration of the ethanol in the concentrated pH-adjusted solution to 5 mass % or lower.