Herpes simplex virus complex

摘要

There is provided an HSV complex which comprises an avirulent HSV and a targeting agent which allows the HSV particle to infect and lyse a specific targeted cell. The inventors have found a way in which avirulent HSV can be targeted to disease cells, e.g. cancer cells, by incorporating an antibody binding domain into one or more viral glycoproteins.

主权项

1. A method of producing an HSV which is capable of targeting a tumor cell which expresses a tumor surface antigen comprising:
(a) modifying the HSV genome by incorporating nucleic acid encoding an antibody binding domain which is expressed as a fusion protein with HSV glycoprotein gC or gD, wherein said antibody binding domain is capable of specifically binding to the tumor surface antigen on the tumor cell; and (b) expressing the modified HSV in a cell.