发明名称 COMPOSITIONS FOR TREATMENT OF CANCER
摘要 Compounds that are specifically toxic to cancer stem cells are disclosed.
申请公布号 US2014194507(A1) 申请公布日期 2014.07.10
申请号 US201313801920 申请日期 2013.03.13
申请人 NovaRx Corporation 发明人 KARIMI-BUSHERI Feridoun;FAKHRAI Habib
分类号 C07D307/73 主分类号 C07D307/73
代理机构 代理人
主权项 1. A pharmaceutical composition comprising as an active ingredient a compound of formula (1) wherein each R1 is a non-interfering substituent independently selected from the group consisting of halo, nitro, OR2, OCOR2, COOR2, R2NCOR2, CONR22, COR2, NR22, S(O)mR2, —CN and R3, where each R2 is independently H or alkyl (1-4) R3 is alkyl (1-6) or substituted alkyl (1-6) wherein the substituents are halo, OR2 or NR22,m is 0, 1 or 2,n is 0, 1 or 2, X is O or S, Y is NR or O, Z is CR2A2 or A, wherein each A is independently phenyl optionally substituted by 1-3 R4 substituents wherein R4 is defined the same as R1 as above, or the pharmaceutically acceptable salts thereof.
地址 San Diego CA US