| 发明名称 |
OVARIAN CANCER STEM CELLS AND METHODS OF ISOLATION AND USES THEREOF |
| 摘要 |
The present invention generally relates to methods, assays, compositions and kits related to a subpopulation of ovarian cancer stem cells which are selected or enriched by chemotherapeutic agents and inhibited by MIS (Mullerian Inhibiting Substance) and MIS mimetics. In particular, the present invention relates to a population of CD44+/CD24+/EpCam+/ECad− subpopulation of ovarian cancer stem cells. The present invention also provides methods to screen a subject with ovarian cancer to identify if they have an ovarian cancer comprising CD44+/CD24+/EpCam+/ECad− ovarian cancer stem cells, and methods to identify and enrich or isolate for such ovarian cancer cell populations. |
| 申请公布号 |
US2014194366(A1) |
申请公布日期 |
2014.07.10 |
| 申请号 |
US201214123551 |
申请日期 |
2012.06.01 |
| 申请人 |
Donahoe Patricia K.;MacLaughlin David T.;Teixeira Jose |
发明人 |
Donahoe Patricia K.;MacLaughlin David T.;Teixeira Jose |
| 分类号 |
G01N33/574 |
主分类号 |
G01N33/574 |
| 代理机构 |
|
代理人 |
|
| 主权项 |
1. A method to identify an ovarian cancer stem cell in a population of cells, comprising measuring the expression of CD24, CD44, EpCam and E-Cadherin in a cell, wherein if a cell is positive for the expression of CD24, CD44, EpCam and negative for the expression of E-Cadherin, the cell is identified as an ovarian cancer stem cell. |
| 地址 |
Boston MA US |
