EFFICIENT CHILLER FOR A SUPERCRITICAL FLUID CHROMATOGRAPHY PUMP

摘要

Methods and systems for pumping compressible fluids in high pressure applications such as high-pressure liquid chromatography (HPLC) or supercritical fluid chromatography (SFC) applications are disclosed. An improved cooling device for a pump head for use in a supercritical fluid chromatography (SFC) system is described. A system for chilling a pumping system, includes a Peltier cooling element in thermal contact with a pump head, wherein the cooling element chills the pump head and a mobile phase fluid flowstream prior to the mobile phase fluid entering the pump; a fluid-cooled heat exchanger, attached to the Peltier cooling element, which removes heat from the cooling element using a circulating fluid; and a second heat exchanger which cools the circulating fluid.

主权项

1. A system for chilling a pumping system, comprising:
a Peltier element arranged adjacent a pump head of a pump such that the Peltier element and the pump head are in thermal contact, wherein the Peltier element is configured to chill the pump head and a mobile phase flowstream prior to fluid from the mobile phase flowstream entering the pump; a first heat exchanger, attached to the Peltier element, configured to remove heat from the Peltier element using a circulating fluid; and a second heat exchanger configured to cool the circulating fluid, wherein the Peltier element and the pump head are arranged in an area that is isolated from the second heat exchanger.