ANTI-HUMAN IL-21 MONOCLONAL ANTIBODIES

摘要

PROBLEM TO BE SOLVED: To provide anti-human il-21 monoclonal antibodies which are expressed as autoimmune disorders and inflammatory disorders and suppress conditions associated with interleukin (IL-21)/IL-21 receptor interactions and biological activity, and a method using the antibodies.SOLUTION: Human anti-human IL-21 monoclonal antibodies and the hybridomas that produce them are disclosed. Some of these antibodies have the ability to bind native human IL-21, a mutant recombinant IL-21 protein and/or peptide regions of human IL-21. These human anti-IL-21 antibodies are useful in therapeutic treatment of autoimmune and inflammatory diseases, particularly diseases mediated by T follicular helper cells, B cells Tcells or T17 cells.