ACYLAMINOCYCLOALKYL COMPOUNDS SUITABLE FOR TREATING DISORDERS THAT RESPOND TO MODULATION OF DOPAMINE D3 RECEPTOR

摘要

The present invention relates to novel acylaminocycloalkyl compounds, in particular to the compounds of the formula I as described herein and to their salts and N-oxides. The compounds possess valuable therapeutic properties and are suitable, in particular, for treating diseases that respond to modulation of the dopamine D3 receptor.;;In formula I, the variables have the following meanings:
m is 1 or 2,n is 1 or 2,A is selected from the group consisting of CH2, CH2CH2, CHFCH2 and CF2CH2,R1 is hydrogen or C1-C3-alkyl,R2 is selected from the group consisting of hydrogen, and fluorine,R3a is selected from the group consisting of hydrogen and methyl,R3b is selected from the group consisting of hydrogen and methyl,R4 is branched C4-C6 alkyl or branched fluorinated C4-C6 alkyl, andR5 is an oxygen containing radical such as C1-C2-alkoxy-C1-C4-alkyl, fluorinated C1-C2-alkoxy-C1-C4-alkyl, hydroxy-C1-C4-alkyl, fluorinated hydroxy-C1-C4-alkyl, oxetanyl, fluorinated oxetanyl, oxolanyl, fluorinated oxolanyl, C3-C5 cycloalkyl, fluorinated C3-C5 cycloalkyl, C3-C5 cycloalkoxy-C1-C4-alkyl and fluorinated C3-C5 cycloalkoxy-C1-C4-alkyl.

主权项

1. A compound of the formula I where m is 1 or 2, n is 1 or 2, A is selected from the group consisting of CH2, CH2CH2, CHFCH2 and CF2CH2, R1 is hydrogen or C1-C3-alkyl, R2 is selected from the group consisting of hydrogen and fluorine, R3a is selected from the group consisting of hydrogen and methyl, R3b is selected from the group consisting of hydrogen and methyl, R4 is branched C4-C6 alkyl or branched fluorinated C4-C6 alkyl, and R5 is an oxygen containing radical selected from the group consisting of C1-C2-alkoxy-C1-C4-alkyl, fluorinated C1-C2-alkoxy-C1-C4-alkyl, hydroxy-C1-C4-alkyl, fluorinated hydroxy-C1-C4-alkyl, oxetanyl, fluorinated oxetanyl, oxolanyl, fluorinated oxolanyl,
C3-C5 cycloalkyl, fluorinated C3-C5 cycloalkyl, where the cycloalkyl moiety in the last two mentioned radicals carries 1 or 2 radicals selected from hydroxyl, C1-C2-alkoxy and fluorinated C1-C2-alkoxy and may additionally carry 1 or 2 radicals selected from C1-C2-alkyl and fluorinated C1-C2-alkyl, C3-C5 cycloalkoxy-C1-C4-alkyl and fluorinated C3-C5 cycloalkoxy-C1-C4-alkyl, where the cycloalkoxy moiety in the last two mentioned radicals may carry 1 or 2 radicals selected from hydroxyl, C1-C2-alkoxy, fluorinated C1-C2-alkoxy, C1-C2-alkyl and fluorinated C1-C2-alkyl, the N-oxides, the prodrugs and the pharmaceutically acceptable salts of these compounds.