ANALGESIC PEPTIDE FROM SEA ANEMONE URTICINA GREBELNYI

摘要

FIELD: chemistry.SUBSTANCE: analgesic peptide has the following amino acid sequence: HN-Ile-Ser-Ile-Asp-Pro-Pro-Cys-Arg-Phe-Cys-Tyr-His-Arg-Asp-Gly-Ser-Gly-Asn-Cys-Val-Tyr-Asp-Ala-Tyr-Gly-Cys-Gly-Ala-Val-COOH. Said peptide can be used as a medicinal agent for treating pathologies associated with tissue acidosis and treating neurologic diseases associated with ASIC3 receptor function, as well as for determining the topology and molecular mechanisms of the function of the ASIC3 channel, and in test systems for detecting and testing novel anti-pain preparations, agonists and antagonists of the ASIC3 receptor.EFFECT: analgesic action owing to inhibition of the functional activity of proton-activated ion channels.9 dwg, 11 ex