MODIFIED TOLL-LIKE RECEPTOR 2 (TLR2) LIGANDS AS INHIBITORS OF NEUTROPHIL RECRUITMENT

摘要

The present invention provides modified TLR2 ligands useful for modulating inflammatory responses. In particular, the ligands comprise (a) a fatty acid di- or tri-linoleate and (b) a GM1-binding peptide. The linoleate provides the anti-inflammatory function, while the GM1-binding peptide facilitates endocytosis.