发明名称 |
PYRROLOBENZODIAZEPINES AND CONJUGATES THEREOF |
摘要 |
<p>A conjugate of formula (A): where Y is selected from a single bond, and a group of formulae A1 or A2: where N shows where the group binds to the N10 of the PBD moiety; RL1 and RL2 are independently selected from H and methyl, or together with the carbon atom to which they are bound form a cyclopropylene group; CBA represents a cell binding agent; Q is independently selected from O, S and NH; R11 is either H, or R or, where Q is O, SO3M, where M is a metal cation.</p> |
申请公布号 |
EP2750713(A1) |
申请公布日期 |
2014.07.09 |
申请号 |
EP20120780356 |
申请日期 |
2012.10.12 |
申请人 |
SPIROGEN SÀRL |
发明人 |
FLYGARE, JOHN, A.;GUNZNER-TOSTE, JANET, L.;PILLOW, THOMAS;HOWARD, PHILIP, WILSON;MASTERSON, LUKE |
分类号 |
A61K47/48;A61P35/00;C07D487/04;C07D519/00 |
主分类号 |
A61K47/48 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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