| 摘要 |
<p>The present invention relates to a novel tetrahydropyridinol derivative compound and to a pharmaceutical composition and health functional food comprising same as an active ingredient for preventing or treating cancer. The novel tetrahydropyridinol derivative compound of the present invention can inhibit the proliferation and invasion of cancer cells by a wnt/β-catenin signal inhibition mechanism through down-regulation ofβ-catenin expression, up-regulation of glyco-gensynthase kinsase 3-β(GSK-3β), or up-regulation of E-cadherin expression, and induce cell cycle arrest of cancer cells through the inhibition of CDK2 expression and the increase of p21 and p27 expression. Therefore, the present invention can be applied to medicine such as a pharmaceutical composition and as well as a health function food as a material which can prevent or treat cancer. Moreover, the novel tetrahydropyridinol derivative of the present invention does not show cytotoxicity to non-tumor cells, and thus the present invention is advantageous for long-term use in terms of safety.</p> |
