Compositions and methods for counteracting effects of reactive oxygen species and free radicals

摘要

Peptide compounds and methods for upregulating expression of a gene encoding an antioxidative enzyme, such as superoxide dismutase or catalase, to counteract harmful oxidative effects of reactive oxygen species and other free radicals are described. The peptide compounds may be used to treat or prevent diseases and conditions characterized by undesirable elevation of reactive oxygen species and other free radicals, to upregulate AP-1 gene expression, and to treat pain. The peptide compounds may be used as components of pharmaceuticals and dietary supplements.

主权项

1. A method of treating an ischemic injury in a subject, the method comprising administering to the subject a peptide compound, wherein the amino acid sequence of the peptide compound is Asp Gly Asp, Asp Gly, Thr Val Ser, or Glu Ala, wherein the peptide compound is administered in an amount effective to treat the ischemic injury, wherein the peptide compound comprises an amino terminal capping group and/or a carboxy terminal capping group.