Optical thromboelastography system and method for evaluation of blood coagulation metrics

摘要

Device, method, and computer program product for determining a material parameter of a blood coagulation cascade based on parameters of light diffused at a biofluid sample. In one example, the biofluid sample includes a blood sample. Laser light scattered by the sample is collected by the optical system in reflection and/or transmission mode. An image of the sample in so collected light is formed, and data representing fluctuations of laser speckle intensity with is processed to derive numerical descriptors associated with blood coagulation and fibrinolysis. In a specific case, such numerical descriptors are derived based on temporal dynamic of a viscoelastic characteristic of the blood sample.

主权项

1. A blood coagulation meter system comprising:
an optical data acquisition system having an input to receive light that has interacted with a stationary blood sample and to acquire data representing scattering of said light by multiple particles in the stationary blood sample; and a processor operably cooperated with said optical data acquisition system and programmed to derive parameters of a blood coagulation cascade from the acquired data, said parameters including clotting time (CT) and at least one of, clot formation time (CFT), maximum clot firmness (MCF), maximum lysis (ML), clot kinetics, percentage of lost clot stability at a selected point in time, rate of clotting, fibrinolysis time, clot compliance, and clot viscosity.