发明名称 |
Methods and compositions related to targeting monoacylglycerol lipase |
摘要 |
This invention provides compounds that selectively inhibit monoacylglycerol lipase (MAGL). The invention also provides methods of using the MAGL selective inhibitors to stimulate 2-Arachidonoylglycerol (2-AG) mediated endocannabinoid signaling in vivo, and to treat conditions that are associated with or linked to endocannabinoid signaling. The invention additionally provides methods of treating cancer or inhibiting tumor growth by targeting MAGL with MAGL specific inhibitors. The invention further provides methods of screening for MAGL inhibitors with improved biochemical and pharmaceutical properties. |
申请公布号 |
US8772318(B2) |
申请公布日期 |
2014.07.08 |
申请号 |
US200912998642 |
申请日期 |
2009.11.10 |
申请人 |
The Scripps Research Institute |
发明人 |
Cravatt Benjamin F.;Long Jonathan Z.;Li Weiwei;Nomura Daniel K. |
分类号 |
A61K31/443;C07D405/06 |
主分类号 |
A61K31/443 |
代理机构 |
|
代理人 |
Wang Hugh;Fitting Thomas |
主权项 |
1. A compound of formula I shown below:wherein X is CH, R1 is H or OH, and R2 and R3 each have the structure |
地址 |
La Jolla CA US |