Glucosamine pro-drug

摘要

To develop glucosamine (GlcN) pro-drugs with properties superior to the presently available GlcN products, we have synthesized derivatives with improved pharmaceutical properties. The synthesized derivatives include peptide-GlcN ester and amide conjugates where the peptide portion consists of one or more amino acids. One such compound is (5-amino-3,4,6-trihydroxyoxan-2-yl)methyl 2-(2-aminoacetamido)-3-methylbutanoate or glycine-valine-COO-GlcN (GV-GlcN).7.

主权项

1. A composition comprising a pharmaceutically acceptable salt or base of compounds chemically containing glucosamine (GlcN) with one or more amino acids attached at the amino or alcohol groups to form amide or ester of the amino-sugar with no ether linkage, wherein said compound is selected from the group consisting of a pharmaceutically accepted salt or base of (5-amino-3,4,6-trihydroxyoxan-2-yl)methyl 2-(2-aminoacetamido)-3-methylbutanoate; a pharmaceutically accepted salt or base of glycine-valine-COO-GlcN (GV-GlcN); and combinations thereof.