| 发明名称 | Therapeutic vaccination against active Tuberculosis | ||
| 摘要 | The invention provides a method for therapeutic treatment of a patient having active tuberculosis (TB), the method comprising: administering to the patient a recombinant adenovirus vector that comprises nucleic acid encoding the Ag85A, Ag85B and TB10.4 antigens of Mycobactium tuberculosis (Mtb). Advantageously, the method can be used to shorten conventional drug therapy for treating active TB. | ||
| 申请公布号 | US8771709(B2) | 申请公布日期 | 2014.07.08 |
| 申请号 | US201113822593 | 申请日期 | 2011.09.19 |
| 申请人 | Crucell Holland B.V. | 发明人 | Sadoff Jerald;Alyahya Anisah |
| 分类号 | A61K39/04;A61K49/00;A61K39/12 | 主分类号 | A61K39/04 |
| 代理机构 | TraskBritt, P.C. | 代理人 | TraskBritt, P.C. |
| 主权项 | 1. A method of treating a patient having active tuberculosis (TB), the method comprising: administering to the patient a recombinant adenovirus vector comprising nucleic acid encoding Ag85A, Ag85B, and TB10.4 antigens of Mycobacterium tuberculosis, and treating the patient further with drug therapy for tuberculosis, wherein the drug therapy comprises: administration of isoniazid, rifampin, pyrazinamide, and ethambutol to the patient. | ||
| 地址 | Leiden NL | ||