发明名称 Imidazole-benzamide anti-cancer agents
摘要 Compounds useful for treating cellular proliferative diseases and disorders by modulating the activity of one or more mitotic kinesins are disclosed.
申请公布号 US8772507(B2) 申请公布日期 2014.07.08
申请号 US201213612690 申请日期 2012.09.12
申请人 Cytokinetics, Inc. 发明人 Qian Xiangping;McDonald Andrew I.;Zhou Han-Jie;Ashcraft Luke W.;Yao Bing;Jiang Hong;Huang Jennifer Kuo Chen;Wang Jianchao;Morgans, Jr. David J.;Morgan Bradley P.;Bergnes Gustave;Dhanak Dashyant;Knight Steven D.;Adams Nicholas D.;Parrish Cynthia A.;Duffy Kevin;Fitch Duke;Tedesco Rosanna
分类号 C07D233/64;C07D231/12;A61K31/415;A61K31/4164 主分类号 C07D233/64
代理机构 代理人
主权项 1. A compound of Formula V: or a pharmaceutically acceptable salt thereof, wherein R2 is selected from hydrogen and lower alkyl;R3 is selected from lower alkyl substituted with hydroxy and lower alkyl substituted with optionally substituted amino;R11 is selected from hydrogen, cyano, nitro and halo;R12 is optionally substituted lower alkoxy;R13 is hydrogen;R14 is 1H-imidazol-4-yl substituted with one, two or three groups selected from optionally substituted lower alkyl, halo, acyl, sulfonyl, cyano, nitro, optionally substituted amino, and optionally substituted heteroaryl; andR15 is selected from hydrogen, halo, hydroxy, and lower alkyl.
地址 South San Francisco CA US