Benzenesulfonyl or sulfonamide compounds suitable for treating disorders that respond to the modulation of the serotonin 5-HT₆receptor

摘要

The present invention relates to benzenesulfonyl or sulfonamide compounds of formulae IA and IB;
wherein the variables have the meanings given in the claims and the description, pharmaceutical compositions containing them, and their use in therapy. The compounds possess valuable therapeutic properties and are particularly suitable for treating diseases that respond to modulation of the serotonin 5-HT6 receptor.

主权项

1. A compound of formula (IA)or a stereoisomer, tautomer, or a physiologically tolerated acid addition salt thereof,
wherein X1 is NR4; R1 is selected from the group consisting of hydrogen, C1-C4-alkyl and fluorinated C1-C4-alkyl; R2 is selected from the group consisting of hydrogen and C1-C4-alkyl; R3 is selected from the group consisting of hydrogen, halogen, C1-C4-alkyl, fluorinated C1-C4-alkyl, C1-C4-alkoxy and fluorinated C1-C4-alkoxy; R4 is selected from the group consisting of hydrogen, C1-C4-alkyl and fluorinated C1-C4-alkyl; R5 is selected from the group consisting of C1-C6-hydroxyalkyl, C1-C6 alkoxy, C1-C6-hydroxyalkoxy, C1-C6-alkoxy-C1-C6-alkoxy, fluorinated C1-C6-alkoxy, fluorinated C1-C6-alkoxy-C1-C6-alkoxy, and a group -A-[O—B]p—O—R7;
whereA and B are independently of each other C1-C4-alkylene or fluorinated C1-C4-alkylene;R7 is C1-C4-alkyl or fluorinated C1-C4-alkyl;p is 0, 1, 2, 3, 4, 5 or 6; R6 is selected from the group consisting of halogen, C1-C2-alkyl, fluorinated C1-C2-alkyl, C1-C2-alkoxy and fluorinated C1-C2-alkoxy; G1 is CH2 or CH2CH2; G2 is CH2 or CH2CH2; o is 0, 1 or 2.