发明名称 |
Prostaglandin and prostamide drug delivery systems and intraocular therapeutic uses thereof |
摘要 |
Biocompatible, bioerodible implants and microspheres include latanoprost and a biodegradable polymer effective, when placed intraocular (such as into the subtenon space) to treat glaucoma. |
申请公布号 |
US8771745(B2) |
申请公布日期 |
2014.07.08 |
申请号 |
US201213596904 |
申请日期 |
2012.08.28 |
申请人 |
Allergan, Inc. |
发明人 |
Robinson Michael R.;Liu Hui;Hughes Patrick M.;Spada Lon T.;Ghebremeskel Alazar N. |
分类号 |
A61K9/14;A61K9/00 |
主分类号 |
A61K9/14 |
代理机构 |
|
代理人 |
Wine Laura L.;German Joel B.;Condino Debra D. |
主权项 |
1. A method of treating glaucoma, the method comprising anterior sub-tenon administration to a patient with glaucoma of a 50-μl pharmaceutical composition consisting of:
(a) a plurality of microspheres made from a PLGA and/or PLA; (b) 1242 micrograms of latanoprost contained by the microspheres, and; (c) 50 μl of a high viscosity hyaluronic acid, the high viscosity hyaluronic acid corresponding to a gel formed of 18 mg of a cross-linked hyaluronic acid in 1 ml of phosphate buffer at pH 7.2, the cross-linked hyaluronic acid having an average molecular weight of about 2 million Daltons, thereby treating the glaucoma. |
地址 |
Irvine CA US |