发明名称 |
Metodo para seleccionar una cepa de bacteria del acido lactico que comprende detectar bacterias por la presencia de un operon histidina activa y seleccionar una cepa que tenga un operon histidina activa y sea capaz de producir histamina; y producto que comprende celulas de dicha cepa. |
摘要 |
A method is provided of selecting specific probiotic lactic acid bacteria producing histamine and the use of such strains for beneficial effects for mammals. The method includes selecting a lactic acid bacterial strain for use in the local production of histamine in a mammal, and further comprises screening bacteria for the presence of an active histidine operon and selecting a strain which has an active histidine operon and is capable of producing histamine. Preferably said strain is selected for its ability to produce histamine at a level of greater than 250 pg/ml. The present invention further provides products comprising the strains obtainable by the selection methods of the invention for use in the local production of histamine in a mammal, in particular for use in the treatment or prophylaxis of inflammatory conditions. |
申请公布号 |
CL2014000128(A1) |
申请公布日期 |
2014.07.04 |
申请号 |
CL20140000128 |
申请日期 |
2014.01.17 |
申请人 |
BIOGAIA AB |
发明人 |
VERSALOVIC, JAMES;THOMAS, CARISA MICHELLE;CONNOLLY, EAMONN |
分类号 |
G01N33/569;A23L1/30;A61K35/74 |
主分类号 |
G01N33/569 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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