Ink Formulation and Manufacture Thereof

摘要

An ink formulation for marking living tissue comprises a dispersion of carbon black pigment particles encapsulated in water soluble shells, mixed with a pharmaceutically accepted carrier, such as water, and a preservative. A dispersion formulation is preferential to a suspension formulation for marking living tissue because the carbon particles of the dispersion formulation are less likely to aggregate and sediment over time. In addition, the absence of large quantities of additives makes a dispersion formulation less reactive to living tissue, further enhancing its appeal as a biological marker.

主权项

1. An ink formulation for marking living tissue, wherein said ink formulation is made by the following process:
a. mixing a pharmaceutically accepted carrier with a preservative to form a carrier-preservative compound; b. pre-wetting a carbon pigment with a first emulsifying agent; c. mixing a second emulsifying agent with glycerin to form an emulsifier-glycerin compound; d. adding said emulsifier-glycerin compound to the pre-wet carbon and mixing until encapsulated carbon particles are formed; and, e. mixing said carrier-preservative compound with said encapsulated carbon particles to form said ink formulation.