IMPROVING THE HALF LIFE OF A THERAPEUTIC POLYPEPTIDE BY FUSING WITH A TRIMERIC SCAFFOLD PROTEIN VIA A SPACER

摘要

A fusion protein comprises of a therapeutic polypeptide and a scaffold protein. The therapeutic polypeptide and the scaffold protein could be connected by a spacer polypeptide. The scaffold protein forms a stable trimeric structure in solution. Also provided are nucleic acids, vectors, pharmaceutical compositions and methods of improving the pharmacokinetic property.