| 摘要 |
There is disclosed a non-naturally occurring microbial organism comprising a first exogenous nucleic acid encoding a first enzyme to produce 1,2-dihydroxy-3,5-cyclohexadiene-1,4-dicarboxylate (DCD) from a dihydroxybenzoate, the first enzyme being either a wild type or a mutant. The non-naturally occurring microbial organism may further comprise a second exogenous nucleic acid encoding a second enzyme to produce terephthalate from 1,2-dihydroxy-3,5-cyclohexadiene-1,4-dicarboxylate. The non-naturally occurring microbial organism may also comprisea third exogenous nucleic acid encoding at least a third enzyme to produce a dihydroxybenzoate from a carbon source, the third enzyme being 3-dehydroshikimate dehydratase. |
