SOLUBLE TUMOR NECROSIS FACTOR RECEPTOR (STNF-R) USED AS A TARGETING AGENT TO TREAT ARTHRITIS AND OTHER DISEASES

摘要

This invention describes the use of sTNF-R as a targeting agent attached to liposomes incorporating anti-inflammatory drugs to treat arthritis and other inflammatory diseases. A variety of steroidal and non-steroidal drugs and disease modifying drugs and other anti-inflammatory compounds may be incorporated into the sTNF-R coated liposomes. The sTNF-R coated drug liposomes will accumulate within the inflamed site where the drug is released for maximum therapeutic effect. Other nanosized drug delivery vehicles such as dendrimers, micelles, nanocapsules and nanoparticles may be similarly coated with sTNF-R and used to deliver the drug to the site of inflammation.

主权项

1. A pharmaceutical composition comprising at least one anti-inflammatory drug encapsulated within a nanosized drug delivery vehicle, wherein a soluble tumor necrosis factor receptor (sTNF-R) is attached to an exterior surface of the nanosized drug delivery vehicle.